MCP server exposing 4 tools for guidetopharmacology.
This URL is a JSON-RPC 2.0 endpoint over HTTP. Issue POST requests with a JSON-RPC body. Browsers and search crawlers land here on GET.
POST https://gateway.pipeworx.io/guidetopharmacology/mcp
Content-Type: application/json
{"jsonrpc":"2.0","id":1,"method":"tools/list"}search_ligands — Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for drug ligands by name. Returns matching ligands with their GtoPdb ligand id, type (e.g. Synthetic organic, Peptide, Antibody, Metabolite), and approval status. Use the returned ligand id with ligand_interactions to find which protein targets it acts on. Keyless. Complements ChEMBL/DrugBank.search_targets — Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for protein targets by name. Returns matching targets with their GtoPdb target id, abbreviation, and type (e.g. GPCR, CatalyticReceptor, Enzyme, Transporter). Use the returned target id with target_interactions to find ligands that bind it. Keyless. Complements ChEMBL/DrugBank.target_interactions — List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.ligand_interactions — List the quantitative target interactions for a drug ligand in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb ligand id (from search_ligands), returns the protein targets it acts on with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.Code samples (curl / TypeScript / one-click client install), schemas, and the live playground are on the pack page:
https://pipeworx.io/packs/guidetopharmacology/
Pipeworx is an open MCP gateway connecting AI agents to live data. pipeworx.io