MCP server exposing 5 tools for gnomad.
This URL is a JSON-RPC 2.0 endpoint over HTTP. Issue POST requests with a JSON-RPC body. Browsers and search crawlers land here on GET.
POST https://gateway.pipeworx.io/gnomad/mcp
Content-Type: application/json
{"jsonrpc":"2.0","id":1,"method":"tools/list"}variant — Variant by chr-pos-ref-alt (e.g. "1-55051215-G-A") or rsid (e.g. "rs1801133"). Coordinates must match the dataset's genome build: the default gnomad_r4 is GRCh38, so a GRCh37/hg19 position will not be found — pass dataset "gnomad_r2_1" for GRCh37.gene — Gene info + variants. Accepts gene symbol (e.g. "BRCA1") or Ensembl gene id.region — Variants in a genomic region (≤25kb recommended). You MUST say which genome build your start/stop are in via assembly — there is no default, because a position is valid in both builds and a wrong guess returns real variants from the wrong locus rather than an error.transcript — Fetch gnomAD variant data for an Ensembl transcript (ENST…), returning transcript coordinates, gene symbol, chromosome position, and per-variant allele counts (ac/an) from exome and genome datasets.search — Autocomplete-style search across gnomAD genes and variants by free-text query; returns matching Ensembl gene IDs with symbols, and matching variant IDs (an rsid resolves here). Use to resolve a partial gene name, symbol or rsid before calling gene or variant.Code samples (curl / TypeScript / one-click client install), schemas, and the live playground are on the pack page:
https://pipeworx.io/packs/gnomad/
Pipeworx is an open MCP gateway connecting AI agents to live data. pipeworx.io