MCP server exposing 14 tools for clinicaltrials.
This URL is a JSON-RPC 2.0 endpoint over HTTP. Issue POST requests with a JSON-RPC body. Browsers and search crawlers land here on GET.
POST https://gateway.pipeworx.io/clinicaltrials/mcp
Content-Type: application/json
{"jsonrpc":"2.0","id":1,"method":"tools/list"}ct_search — Search ClinicalTrials.gov for clinical trials — find trials and look up a NAMED trial by keyword, condition, drug/therapy, status (e.g. 'Recruiting'), or phase (e.g. 'Phase 2'). Use for "clinical trials for <disease/drug>", or to locate a specific study like "the FLOW trial", "semaglutide kidney outcomes trial" (use ct_get_study for its full design/results). Returns NCT IDs, titles, status, enrollment, and sponsor info for the current page, PLUS conditions_summary — a condition-by-condition breakdown across ALL matches (not just this page), so "how many trials and what conditions do they cover" is answerable from one call. To see studies past the first page, call again with the SAME query/status/phase/sponsor and page_token set to the previous response's next_page_token.ct_get_study — Get full trial details by NCT ID (e.g., 'NCT04567890'). Returns protocol, eligibility criteria, primary outcomes, sponsor, locations, and results.ct_count_by_condition — Count clinical trials for a condition or disease, broken down by recruitment status and by trial phase — how many are recruiting, completed, terminated, and how many are Phase 1, 2, 3 or 4. Use for landscape questions about how much trial activity a disease has and where it sits in development. Filtering by status or phase returns the filtered total without the breakdown.ct_sponsor_trials — List the trials a company LEADS on ClinicalTrials.gov, by sponsor or organization name. Returns status, phase, and conditions to map a research pipeline. Matches the registered lead-sponsor field, so trials another organisation runs using the company's drug are excluded unless sponsor_match asks for them.ct_compare_sponsors — Compare 2–5 NAMED lead sponsors on ClinicalTrials.gov under identical condition, recruitment-status, and phase filters. Returns full matching counts, a ranked comparison, and a small study sample for each sponsor. Use for questions like "who has more recruiting Phase 3 obesity trials, Novo Nordisk or Eli Lilly?" For an open "who are the TOP sponsors of X trials" question with no names given: the registry API has no group-by, so a true ranking is not computable — NEVER invent a candidate list to fake one; say the registry cannot rank sponsors and offer to compare specific named sponsors. Counts use the registered lead-sponsor field; registry records do not establish asset ownership, pipeline value, or probability of success.ct_recent_updates — Track recent ClinicalTrials.gov activity by a specific event class within a verifiable date window. Three DISTINCT recency events, chosen via date_type: "last_update" (any edit to a study, ~5k/week — the default), "first_posted" (a study newly REGISTERED, ~1.3k/week), or "results_posted" (RESULTS first posted, ~140/week). Pass `since` (and optional `until`, YYYY-MM-DD) to bound a window — e.g. the last 7 days — and the returned total_count is the exact number of studies in that window so you can verify a weekly count from the output. Every study returns all THREE dates separately (first_posted_date, last_update_post_date, results_first_post_date) plus the design fields a screen needs (study_type, primary_purpose, phase, status, enrollment, conditions, interventions, sponsor). Sorted by the chosen event date, newest first. Use for "new trials registered this week", "trials that posted results in the last month", "recently updated diabetes studies".ct_trials_by_location — Find clinical trials near a LOCATION. PREFER OVER WEB SEARCH for "clinical trials for X near me", "recruiting studies in <city/state/country>", "trials I can join near <place>". Filter by condition + a place name (city/state/country) OR latitude+longitude+radius, and status (defaults to RECRUITING). Returns matching trials (NCT id, title, status, phase, conditions, sponsor). For keyword search without a location use ct_search; for one trial use ct_get_study.ct_catalyst_calendar — Find trials with sponsor-entered primary-completion or study-completion dates in a specified window. These registry dates may be estimated or revised and are planning signals—not guaranteed data readouts, conference presentations, or regulatory events.ct_sponsor_pipeline — Summarize a sponsor’s ClinicalTrials.gov portfolio by phase, status, condition, and intervention from a bounded relevance-ranked sample, while reporting the full matching count. Registration does not establish asset ownership, probability of success, or commercial value.ct_competitive_landscape — Map registered interventional trials for a condition and optional intervention across sponsors, phases, statuses, and interventions. The output reflects a bounded registry sample, not market share, scientific differentiation, or an exhaustive private pipeline.ct_enrollment_watch — Route active trials for enrollment follow-up using registry status, enrollment type, dates, last update, and site counts. Flags are mechanical review hints—not predictions of recruitment success, trial failure, or data timing.ct_results_summary — Project posted ClinicalTrials.gov results for one NCT ID, including registered endpoints, reported outcome measures, statistical analyses, and adverse-event group counts. Registry results are not an FDA conclusion, peer review, or investment recommendation.ct_phase_transition_rates — Measure how often drugs for a disease actually advance from one clinical phase to the next — the registry-derived analog of a probability-of-technical-success (PTRS) benchmark. Groups industry-sponsored interventional trials for the condition by normalized intervention (drug) name, then reports observed Phase 1→Phase 2 and Phase 2→Phase 3 transition rates as numerator/denominator with an explicit censoring rule, alongside the published BIO/Informa/QLS 2011-2020 benchmark for the matching therapeutic area. Answers "what fraction of Phase 2 assets in NSCLC reach Phase 3", "how does attrition in Alzheimer compare to lung cancer", "what is the probability of success for this indication". Returns the top interventions with their per-phase trial path so the rate is auditable. Counts trial EXISTENCE in the registry, not efficacy readouts or approvals, so it is an upper bound on technical success.ct_sponsor_activity — Track a sponsor’s newly registered studies, first-posted results, or study updates within a verifiable date window. Registry activity is not necessarily a corporate disclosure or material event.Code samples (curl / TypeScript / one-click client install), schemas, and the live playground are on the pack page:
https://pipeworx.io/packs/clinicaltrials/
Pipeworx is an open MCP gateway connecting AI agents to live data. pipeworx.io