MCP server exposing 4 tools for civic.
This URL is a JSON-RPC 2.0 endpoint over HTTP. Issue POST requests with a JSON-RPC body. Browsers and search crawlers land here on GET.
POST https://gateway.pipeworx.io/civic/mcp
Content-Type: application/json
{"jsonrpc":"2.0","id":1,"method":"tools/list"}civic_search_genes — Find cancer genes and fusions in CIViC by name or symbol, with how much curated clinical evidence each carries (variant count, evidence-item count, assertion count). AUTHORITATIVE starting point for "what does CIViC know about gene X" — CIViC is the open expert-curated knowledgebase of clinically actionable somatic cancer variants. Returns the numeric CIViC feature id you pass to the other tools.civic_gene_variants — Curated variants of a cancer gene in CIViC — the specific alterations (missense, fusion, amplification, exon-level) that have published clinical interpretations, each with its evidence count, associated diseases and therapies. AUTHORITATIVE for "which variants of this gene are clinically actionable". Pass the gene symbol.civic_variant_evidence — Individual CIViC evidence items for a molecular profile — the graded, source-linked statements that a variant predicts response or resistance to a therapy, carries prognostic or diagnostic weight, or is oncogenic. Each item carries evidence type, level (A-E), direction, significance, 1-5 star rating, disease, therapies and the PubMed/ASCO source. AUTHORITATIVE for the clinical evidence behind a variant claim, rather than a summary of it. Pass a molecular profile name such as "BRAF V600E", or a numeric CIViC variant id.civic_assertions — CIViC assertions — the curated, AMP/ASCO/CAP-tiered and ACMG-classified clinical summaries that roll up multiple evidence items into a single actionable statement, including FDA companion-test and regulatory-approval flags. AUTHORITATIVE for "is this variant clinically actionable in this disease, and at what tier". Filter by molecular profile, disease or therapy.Code samples (curl / TypeScript / one-click client install), schemas, and the live playground are on the pack page:
https://pipeworx.io/packs/civic/
Pipeworx is an open MCP gateway connecting AI agents to live data. pipeworx.io